THE PURINE METABOLISM OF A 6-MERCAPTOPURINE-RESISTANT LACTOBACILLUS CASEI
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چکیده
منابع مشابه
Pentitol metabolism in Lactobacillus casei.
Strains of Lactobacillus casei capable of growing on either ribitol or xylitol carry out a heterolactic fermentation producing ethanol, acetate, and a mixture of D- and L-lactate. Following conversion of the pentitols to ribulose 5-phosphate or xylulose 5-phosphate via enzymatic steps unique to these organisms, the intermediate products are further metabolized by enzymes of the pentose pathway....
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Coggin, Joseph H. (University of Chicago, Chicago, Ill.), Muriel Loosemore, and William R. Martin. Metabolism of 6-mercaptopurine by resistant Escherichia coli cells. J. Bacteriol. 92:446-454. 1966.-6-Mercaptopurine (MP) utilization as a source of purine in MP-sensitive and -resistant cultures of Escherichia coli was investigated. The label of MP-8-C(14) appeared in adenine and guanine of ribon...
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Leukemia L1210 ascites tumor cells sensitive to inhibition by 6-mercaptopurine were observed to metabolize hypoxanthine-8-C14 and 6-mercaptopurine-S36 to ribonucleotide derivatives in vivo. Hypoxanthine-8-CH extensively labeled adenylic and guanylic acids of L1210 nucleic acids. Soluble enzyme preparations from L1210 ascites cells catalyzed the reactions of adenine, guanine, 8-azaguanine, hypox...
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(6-MP)' are so numerous that it becomes especially diffi cult to determine which metabolic block is responsible for the inhibition of growth. Yet, the usefulness of this drug in the control of human leukemia encourages ever deeper probing into its biochemical effects. One obvious need is to study the metabolic blocks simultaneously, insofar as possible. The technics of paper chromatography and ...
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The compound 6-mercaptopurine (6-MP) has been shown to possess definite antitumor (13) properties and to inhibit the growth of several microorganisms (14-16). This inhibition has been reversed by several purines (14-16), and it is possible that the antitumor action is also con cerned with purine metabolism. The present exper iments were undertaken in an attempt to elucidate the action of 6-MP b...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1953
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)66112-5